Veterinary Laboratory Toronto
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Available Tests


Canine Globoid Cell Leukodystrophy (Code: C118)

TEST DESCRIPTION

Canine Globoid Cell Leukodystrophy is a storage disease, one of a relatively rare group of disorders in which there is a deficiency of a particular enzyme necessary for normal metabolic processes within the body. The result is an accumulation in cells ("storage") of whatever product the enzyme normally acts upon. Typically, animals with a storage disease are normal at birth, fail to grow as rapidly as littermates, and at a consistent age, develop progressive signs of a disorder of the nervous system which will ultimately be fatal. In Canine Globoid Cell Leukodystrophy, the lack of the enzyme galactocerebrosidase results in an accumulation of galactocerebroside, a component of myelin. This disrupts the cells that normally produce myelin, a fatty substance that coats nerve cells, serves as an electrical insulator and is crucial to the normal conduction of nerve impulses. The progressive loss of myelin in the white matter tracts of the nervous system (brain, spinal cord and/or peripheral nerves) causes a variety of clinical signs such as lack of coordination, tremors, and weakness. Puppies affected with this disease are normal at birth but grow more slowly than their littermates, and begin to to show signs of incoordination by 3 to 6 months. (In basset hounds the signs are seen later, between 1.5 and 4 years of age.) You may see tremors, a stiff gait, weakness, poor balance (falling to one side, stumbling), changes in behaviour or attitude, and vision changes. The disease is rapidly progressive over a few months in Cairn and West Highland White Terriers. The disease is invariably fatal, and affected dogs generally die or are euthanized before adulthood. The progression is slower in miniature poodles, over 2 to 4 years.

DNA Test

This DNA test provides reliable identification of dogs that carry mutant gene(s). This test allows a breeder to control the mutant gene frequency in Cairn and West Highland White Terriers thus preventing the production of puppies affected with Canine Globoid Cell Leukodystrophy. This DNA test accurately and specifically identifies normal, carriers (heterozygous) and affected dogs.

TEST IS AVAILABLE FOR THE FOLLOWING BREEDS
Cairn Terrier
West Highland White Terrier
PRICING
$85 US
$85 CDN (subject to HST - Canadian residents only)

Special contract prices are available for Breeder Clubs. Please contact us for more information.
CERTIFICATION OF RESULTS
HealthGene will provide a certificate for each test result.
SAMPLES
The following sample(s) can be submitted for the testing:
A blood sample in a lavender (EDTA) tube
Cheek swabs
REPORTING RESULTS
Test results are usually available in 10 business days from the moment the samples arrive at the laboratory. Test results can be reported by e-mail, fax, or by phone.