Veterinary Laboratory Toronto
Call Us! 1-877-371-1551

Request Information

Fill out the form below and one of our executives will get in touch with you.


Available DNA Tests for Dogs and Cats

Canine Congenital Stationary Night Blindness (Code: C116)


The Briard dog is affected with an inherited retinal disorder characterized by congenital night blindness with various degrees of visual impairment under photopic illumination. Vision in affected dogs ranges from normal day vision to profound day blindness. The symptoms include night blindness and a loss of vision in daylight that can vary between individual dogs. he disease shows an autosomal recessive mode of inheritance; therefore. two copies of the defective gene, one inherited from each parent, have to be present for a dog to be affected by the disease.

DNA Test

A DNA-based test is now available for the detection of Congenital Stationary Night Blindness in Briards. This test utilizes molecular probes that are 100% specific for the detection of the gene (RPE65) associated with CSNB. Using the PCR, RPE65 is detected, amplified, and the results are interpreted to determine whether the mutation for CSNB is present in two copies (homozygous recessive), or whether the dog is a carrier of the mutation (heterozygous). Dogs that are diagnosed as having two copies of the mutation show clinical symptoms of the disease in as early as 5-6 weeks of age. Dogs that are diagnosed as carriers show no signs of the disease but are still able to produce affected pups. It is important to eliminate such carriers from a breeding population since they represent a hidden reservoir of the disease that can produce affected dogs at any time, depending on the genetic standing of their mate. This test provides definitive information on the genetic status of this disease, giving breeders the information to eradicate the disease from their lines.

$68 CDN (subject to HST - Canadian residents only).
HealthGene will provide a certificate for each test result.
The following sample(s) can be submitted for the testing:
1. Blood sample in a lavender (EDTA) tube.
2. Cheek swabs.
Test results are usually available in 10 business days from the moment the samples arrive at the laboratory. Test results can be reported by e-mail, fax, or by phone.