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Available DNA Tests for Dogs and Cats

Canine Pyruvate Kinase Deficiency (Code: C108)


Canine Pyruvate Kinase Deficiency, also known as erythrocyte pyruvate kinase deficiency, is a syndrome of hemolytic anemia. Pyruvate Kinase (PK) is a regulatory enzyme found within red blood cells. Red blood cells (erythrocytes) that are deficient in the PK enzyme rupture prematurely causing hemolytic (red cell rupture) anemia. Indications of anemia include: very pale mucous membranes (gums, eye lids, etc.), increased heart rate and pounding pulses, generalized weakness and an intolerance to exercise or activity. The liver and spleen of anemic dogs may be enlarged. In dogs over one year of age, the density of the bones appears, radiographically, increased. If the dog has a relatively inactive life, it may not exhibit any obvious indications of a problem. Most often this condition is detected, through clinical indications, in dogs between the ages of four months and one year, although this condition can remain undetected until later in life. Most sufferers of Pyruvate Kinase Deficiency die between the ages of one to four years, due to progressive anemia or liver failure.

DNA Test

This DNA test provides the reliable identification of dogs that carry mutant gene(s). The DNA test allows a breeder to control the mutant gene frequency in Basenji and West Highland White Terrier breeds, thus preventing the production of puppies affected with Canine Pyruvate Kinase Deficiency. This DNA test accurately and specifically identifies normal, carriers (heterozygous) and affected dogs.

West Highland White Terrier
$48 US
$48 CDN (subject to HST - Canadian residents only).
HealthGene will provide a certificate for each test result.
The following sample(s) can be submitted for the testing:
1. Blood sample in a lavender (EDTA) tube.
2. Cheek swabs.
Test results are usually available in 10 business days from the moment the samples arrive at the laboratory. Test results can be reported by e-mail, fax, or by phone.