C136 - Canine Cyclic Neutropenia (Gray Collie Syndrome)

Canine Cyclic Neutropenia is a stem cell disorder that occurs in gray collies. Puppies are usually smaller and weaker than their littermates and by 8 to 12 weeks of age they develop clinical signs such as fever, diarrhea, joint pain, or other signs associated with eye, respiratory, or skin infections.
The disorder is caused by an abnormality of the stem cells in the bone marrow, from which all blood cells are developed. The result is a cyclic fluctuatian in blood cell numbers. Every 10 to 12 days the number of neutrophils drops dramatically, and then rebounds. There is an increased susceptibility to infection corresponding to the dip in neutrophil numbers. Affected dogs are subject to severe recurring bacterial infections, primarily of the respiratory or gastrointestinal tract. These dogs are also prone to bleeding episodes due to the drop in blood cells numbers. This is a serious genetic disorder. Even with the best of care, affected dogs rarely live beyond 2 or 3 years of age.
The disease occurs in all gray (not merle) collies. Affected puppies have a silver gray hair coat, sometimes with a slight yellowing due to a mixture of light beige and light gray hair.

The mode of inheritance is autosomal recessive. Both parents must carry the abnormal gene for the offspring to be affected.

HealthGene Laboratory is the first DNA diagnostic laboratory that has developed and offered a DNA-based test for Canine Cyclic Neutropenia. HealthGene's test provides a reliable identification of dogs that carry mutant gene(s). This test allows a breeder to control the mutant gene frequency in the Collie breed thus preventing the production of puppies affected with Canine Cyclic Neutropenia. Thsi DNA test accurately and specifically identifies normal, carriers (heterozygous) and affected dogs.