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CODE: C136
INTRODUCTION:
DESCRIPTION
Canine Cyclic Neutropenia is a stem cell disorder that occurs in gray collies. Puppies are usually smaller and weaker
than their littermates and by 8 to 12 weeks of age they develop clinical signs such as fever, diarrhea, joint pain,
or other signs associated with eye, respiratory, or skin infections.
The disorder is caused by an abnormality of
the stem cells in the bone marrow, from which all blood cells are developed. The result is a cyclic fluctuatian in
blood cell numbers. Every 10 to 12 days the number of neutrophils drops dramatically, and then rebounds. There is an
increased susceptibility to infection corresponding to the dip in neutrophil numbers. Affected dogs are subject to
severe recurring bacterial infections, primarily of the respiratory or gastrointestinal tract. These dogs are also
prone to bleeding episodes due to the drop in blood cells numbers. This is a serious genetic disorder. Even with the
best of care, affected dogs rarely live beyond 2 or 3 years of age.
The disease occurs in all gray (not merle)
collies. Affected puppies have a silver gray hair coat, sometimes with a slight yellowing due to a mixture of light
beige and light gray hair.
INHERITANCE
The mode of inheritance is autosomal recessive. Both parents must carry the abnormal gene for the offspring to be affected.
DNA TEST
HealthGene Laboratory is the first DNA diagnostic laboratory that has developed and offered a DNA-based test for Canine
Cyclic Neutropenia. HealthGene's test provides a reliable identification of dogs that carry mutant gene(s). This test
allows a breeder to control the mutant gene frequency in the Collie breed thus preventing the production of puppies
affected with Canine Cyclic Neutropenia. Thsi DNA test accurately and specifically identifies normal, carriers
(heterozygous) and affected dogs.
BREEDS:
Collie (Rough)
Collie (Smooth)
TEST RESULTS:
| Result |
Interpretation |
| Normal |
Homozygous for normal gene, will never develop the disease |
| Carrier |
Carries one mutant gene, but will never develop the disease |
| Affected |
Homozygous for disease gene and will develop the disease |
SAMPLES:
One type of sample can be submitted for this DNA test: a blood sample in a lavender (EDTA) tube.
Blood can be collected
by your veterinarian or a licensed veterinary technician and must be submitted with the HealthGene's submission form
(download submission form).
HealthGene
does not supply sample collection kits since your veterinarian will have the necessary supplies.
Collect 3ml of blood in a
lavender (EDTA) tube from the dog. Do not freeze the sample at any time. Refrigeration is recommended if the sample will not
be shipped on the day that it is collected.
Use the following couriers to ship samples to the laboratory:
1. Federal
Express requires the outer rigid package be at least 7 x 4 x 2 inches in size. If it is smaller, it must be inserted into
a plastic "Diagnostic Specimen Envelope" provided by them.
2. DHL Express requires the package be inserted into their
green bag "lab pac". You should request one when you schedule a pick-up.
PRICE:
-$170.00 *
Special contract prices are available for Breeder Clubs. Please contact us for more information.
* - subject to the applicable taxes (5% GST Canadian Residents only)
CERTIFICATION OF RESULTS:
HealthGene will provide a certificate for each test result.
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